Worldwide Studies on Stevia

Contrary to what many would have you believe, plenty of research has been done touting the benefits of stevia, with no side effects reported.  These research studies have been compiled for your perusal here, so take your time and enjoy reading these. 


Many of the following are copies of the abstracts that summarize the findings, but if you want the full report on a study, you can contact the NIH site or the publication directly. Here is a summary of their conclusions:


“Stevia and stevioside are safe when used as a sweetener.”


“It is suited for diabetics… obese persons… and PKU patients.”


“No allergic reactions to it seem to exist.”


“Stevioside may be advantageous in the treatment of type 2 diabetes.”


“Stevioside acts as an antihyperglycemic and a blood pressure-lowering substance; effects that may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.”


“Stevioside…was effective in blood pressure reduction.”


“Neither stevioside nor rebaudioside A is cariogenic.”


“In this 2-year study in Chinese patients with mild hypertension, oral stevioside significantly decreased systolic blood pressure and diastolic blood pressure compared with placebo. Quality of life was improved, and no significant adverse effects were noted.”


“Stevioside is an effective antihypertensive natural product."


For the details, click on the following:

1. Stevioside.
Phytochemistry. 2003 Nov;64(5):913-21. Review.


2. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.
Braz J Med Biol Res. 1986;19(6):771-4.


3. Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Metabolism. 2004 Jan;53(1):73-6.


4. Effect of stevioside on growth and reproduction.
Hum Reprod. 1991 Jan;6(1):158-65.


5. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity.
Metabolism. 2000 Feb;49(2):208-14.


6. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat.
Metabolism. 2003 Mar;52(3):372-8.


7. Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats..
Horm Metab Res. 2005 Oct;37(10):610-6.


8. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats.
Life Sci. 1998;63(19):1679-84.


9. Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A.
Caries Res. 1992;26(5):363-6.


10. Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats.
Metabolism. 2005 Sep;54(9):1181-8.


11. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana.

 Planta Med. 2005 Feb;71(2):108-13.


12. Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependency.
Metabolism. 2004 Oct;53(10):1378-81.


13. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
Clin Ther. 2003 Nov;25(11):2797-808.


14. Mechanism of the antihypertensive effect of stevioside in anesthetized dogs.
Pharmacology. 2003 Jan;67(1):14-20.


15. Antihypertensive effect of stevioside in different strains of hypertensive rats.
Zhonghua Yi Xue Za Zhi (Taipei). 2002 Jan;65(1):1-6.


Copyright 2011, 2006 by Lisa Jobs and Healthy Lifestyle Publishing LCC